| ! | Black & Gold Meet Records | 41.22 | Central Connecticut | 4/1/2022 |
| Team | Squad | Athlete 1 | Athlete 2 | Athlete 3 | Athlete 4 | Seed | Note | |
|---|---|---|---|---|---|---|---|---|
| 1 | UMass Amherst |
A | Perry | Clark | Walsh | Rodia | 41.71 | Holy Cross Invitational 2022 |
| 2 | Sacred Heart |
A | Hibbert | Mahon | Mahario | Brinken | 42.11 | NEICAAA Outdoor Track & Field Championships |
| 3 | Bryant |
A | Sivo | Smith | Dawkins | Smith | 42.13 | NEICAAA Outdoor Track & Field Championships |
| 4 | Holy Cross |
A | Barone | Punni | Bergin | Fennelly | 42.40 | |
| 5 | Maine |
A | Cotton | Jones | Cruz | Martin | 42.80 | |
| 6 | Merrimack |
A | Crowley | Smith | Smith | Rahaman | 43.00 | |
| 7 | UMass Amherst |
B | Gonzalez | Harden | Matthews | Gaskins | 43.00 | |
| 8 | Holy Cross |
B | O'Connell | Exantus | Lloyd | Flaherty | 43.50 | |
| 9 | RIC |
A | Briggs | Karweh | Nayte | Doss | 43.50 | |
| 10 | Merrimack |
B | Recto | McKoy | Manti | Mighty | 44.00 | |
| 11 | Wheaton (Mass.) |
A | Hart | Almas | Goncalves | Peterson | 44.57 | Alan Connie Shamrock Invitational |
| 12 | Wheaton (Mass.) |
B | Cahill | Plympton | Mualis | Pinnix | 44.91 | |
| 13 | Coast Guard |
A | Castro | Griffin | Bolin | Smith-Custer | 45.00 | |
| 14 | Wheaton (Mass.) |
C | Wojtowicz | Ventura | Giatrakos | Singer | 45.31 |